Biomaterials – ME 765
Fall 2003: Tuesday/Thursday 1:00 pm – 2:20 pm
Instructor: Lisa Friis, Ph.D., Assistant Professor, Mechanical Engineering
Room 3134, Learned Hall
Office phone: 864-2104
Email: lfriis@ku.edu
Office Hours: Tuesday: 2:30 pm – 4:00 pm
Wednesday: 8:30 am – 9:30 am
Thursday: 9:30 am – 11:00 am… or by appointment if necessary
Text: Biomaterials: Principles and Applications, Edited by J.B. Park and J.D. Bronzino, CRC Press, 2033, ISBN 0-8493-1491-7
Course Objectives: By the end of the course, students should be able to …..
Course Policy on Academic Dishonesty:
Academic dishonesty (cheating) will not be tolerated in the School of Engineering. In this course, cheating will be defined as sharing information during Examinations or Quizzes, direct copying of homework assignments or laboratory reports, allowing others to do the majority of the work for your projects, and plagiarism on the reports, homework assignments, papers or projects. (For an excellent definition of plagiarism with examples, see http://www.ehhs.cmich.edu/~mspears/~plagiarism.html). In this course it is okay to ask each other questions on the homework assignments (but not on Take-Home Exams). This implies that each student has individual active input on every problem or assignment. Tag teams efforts on homework assignments are not allowed and submission of identical homework is not permitted. Cheating in class is inconsistent with professional engineering ethics and is a serious violation. If any student is found cheating, he/she will be dealt with in a forthright and no nonsense manner. The instance will be reported with documentation to the Associate Dean and appropriate penalties will be invoked.
Course Grading Structure
KU Grading System (adapted from the University Senate Rules and Regulations “Article II, Section 2: The Grading System”, http://www.ku.edu/~unigov/usrr.html#art2sect2)
The letters A, B, C, D shall be used to indicate passing work.
The letter F shall indicate that the quality of work was such that, to obtain credit, the student must repeat the regular work of the course, or that the student’s work was not of passing quality at the time of disenrollment from the course.
Breakdown of total points available:
Examination I ………………………………….. 125 points (25%)
Examination II …………………………………. 150 points (30%)
Final Exam …………………………………….. None
Homework ……………………………………... 60 points
Journal Club …………………………………… 15 points (20%)
Medical Device Analysis ……………………… 25 points
Research Proposal and Presentation …………... 125 points (25%)
In general, reported earned grades will follow these general guidelines:
Outstanding quality ( A ) equates to 90 – 100% of the total available points.
High quality ( B ) equates to 80 – 90% of the total available points.
Acceptable quality ( C ) equates to 70 – 80% of the total available points.
Minimally passing quality ( D ) equates to 60 – 70% of the total available points.
Not passing quality ( F ) equates to less than 60% of the total available points.
***** Borderline scores will be affected by class attendance and participation. *****
Notice: I do not curve grades in this course. It is theoretically possible for everyone in the class to get an A (or an F). Your performance depends on ly on how you do, not on how everyone else in the class does. It is therefore in your best interest to help your classmates in every legal and ethical way possible.
Gray areas between guaranteed letter grades
There will be a “gray area” of several points below the specified numerical cutoff grades, within a ± system will be sued. Two people getting the same weighted average grade (say, 89%) might therefore get different course grades (A or B). If you are in one of these gray areas, whether you get the higher or lower grade depends on whether your test performance has been improving (your grade goes up) or declining (it goes down), and whether your participation in group work has been good (up) or inadequate (down).
Homework
Completed assignments should be turned in by the beginning of class on the due date in class. Unless the assignment specified otherwise, you must work in teams of two or three, handing in one team solution per assignment. It is strongly suggested that each team member should set up each problem individually (read in advance, define the unknowns, outline the solution procedure), then get together to work out the details. On some assignments, this procedure will be required and your instructor will ask for the individual outlines to be signed and turned in.
Team roles for homework
On each group assignment, you and your homework partner must designate
The team roles must rotate on every assignment – once a team member has carried out a role, he/she may not do it again until everyone else on the team has done it.
Homework format
Use engineering paper, one side of each page. Each problem should either be on a new page, or clearly marked between problems. Each completed assignment should be in one person’s handwriting (the recorder’s). Staple the pages and fold them vertically when you hand them in, putting the names and roles (coordinator, recorder, checker) of the participating group members and the problem set number and date on the outside. If a student’s name appears on a solution set, it certifies that he/she participated in solving the problems.
To present the problem solution, start with restating (preferably in your own words) what was given in the problem, what you are to find, and then provide your solution as such:
Given:
Find:
Solution:
The final answer to the problem (if numerical) should be encompassed by a line box or indicated by an arrow (if written).
Late Homework
Homework is considered late if turned in after the end of the class period on the day due. Late homework will be accepted, but penalties will also be imposed as follows:
One (1) day late: 50% deduction from total score.
Two (2) days late: 75% deduction from total score.
Three (3) or more days late: 100% deduction (no credit).
Special exceptions to the late homework policy will be announced in lecture in the case of homework due the class period before an examination.
Individual effort assessments for team homework and projects
All students will periodically be asked to submit evaluations of how well then and their teammate performed as team members. These evaluations will be incorporated into the assignment of homework grades. If repeated efforts to improve team functioning (including faculty intervention) fail, a non-participant member may be fired by the other team member(s). Similarly, a team member doing essentially all the work may quit. Individuals who quit or are fired must find a team of two unanimously willing to accept them; otherwise they will receive zeros for the remainder of the homework.
Tests
There will be two midterm exams. The point layout of these exams is given on the previous page.
Missed tests
If you miss a test without either a certified medical excuse or prior instructor approval, you may take a makeup test at a designated time near the end of the semester. Only one makeup test will be given. It will be fair, but challenging! Tests missed with certified medical excuses of sufficient severity or prior instructor approval will be dealt with individually. If you miss the final exam without a valid excuse, a zero will be averaged into your grade.
Disability services
The staff of Services for Students with Disabilities (SSD), 135 Strong, 785-864-2620 (v/tty), coordinates accommodations and services for KU courses. If you have a disability for which you may request accommodation in KU classes and have not contacted them, please do as soon as possible. Please also see me privately in regard to this course.
Consulting with faculty
I strongly encourage you to discuss academic or personal questions about this course with your course instructor during my office hours or by email. Office hours are set for you – I welcome questions and interaction with you during these times.
Descriptions of Special Projects
Journal Club: Three Journal Club sessions (one after each Midterm Examination and one at the end of the semester) will be held. For Journal Club, journal article titles will be presented to the class. Each student must choose one of the articles to read and critique. Each article will be3 read by all students who choose that article independently outside of class. The two or three students who choose an article form a group – this group may be different from the teams that work together on homework. Before the article is discussed in class, each student will individually prepare an individual written review of the article (format to be distributed later). During the Journal club class session, each group will then discuss the article first within their group and prepare an informal presentation and critique of the article to the rest of the class. The purpose of this exercise is to learn more about current technology in the field of biomaterials and to develop skills in critical review of research. Journal Club points are earned by completing the individual written review and participation in class.
Biomaterials Research Project Development and Presentation: A “library research” and proposal preparation project will be either assigned to or chosen by each team. Teams may be the same as those for the homework assignments or may be different. Teams should consist of at least three students unless class numbers prohibit this arrangement. In this project, each team will explore a research question in the biomaterials field. The team will explore the biomaterials research question through a review of the literature on the subject matter, come up with a reasonable method to study the research question, determine the budget, equipment and personnel expertise required to study the project, and present this information in the form of an NIH style format proposal. Examples of topics are the use a biomedical material in a specific implant (i.e., an SBIR proposal), processing concerns with a specific biomaterial or special problems associated with a specific biomaterial. Please discuss your topic choice with the instructor before doing extensive background work. Each team member will be assigned a role on the project and will represent an area of expertise on the study. Students will be required to write the specific aims, background and literature, and research design sections according to NIH guidelines. The team must then present their proposed research question, literature review, budget and study design to the class for review and critique. Further details on the proposal project and presentation will be given throughout the semester.
Medical Device Analysis: Each team of students will choose a real medical device from our KU supply to analyze. A variety of different devices are available. Students must carefully “dissect” the product, making note of how it was packaged, how/why it was labeled, what materials were used in packaging, sterilization concerns, what materials were used in the device, how the device functions, etc. Each team will prepare a report on these issues to submit to the instructor. Teams will then given an informal presentation of their analysis to the class in a group discussion format. More details on this analysis will be given during the semester.
| Week | Dates | Topic Area | Associated Reading | Assignment Status |
| 1 | ||||
| 08/21/03 | General Discussion, Ground Rules and Expectations | |||
| 2 | 08/26/03 | Structure of Solids | Class Notes | 1st Homework Assigned |
| 08/28/03 | Characterization of Materials | Class Notes | ||
| 3 | 09/02/03 | Characterization, cont. | Medical Device Assignment | |
| 09/04/03 | Metallic Implant Alloys | Chapter 1, text | 1st Homework Due 2nd Homework assigned |
|
| 4 | 09/09/03 | Metals, cont. | ||
| 09/11/03 | Ceramic Biomaterials | Chapter 2, text | 2nd Homework due | |
| 5 | 09/16/03 | Polymeric Implant Materials | Chapter 3, text | 3rd Homework assigned |
| 09/18/03 | Polymers, cont. | Chapter 5, text | ||
| 6 | 09/23/03 | Composite Biomaterials | Chapter 4, text | Journal Club I articles assigned |
| 09/25/03 | "Catch-up", Review for Exam I | 3rd Homework due | ||
| 7 | 09/30/03 | Examination I | ||
| 10/02/03 | Journal Club I | |||
| 8 | 10/07/03 | Review results of Exam I Structure Property Relationship of Biological Materials |
Chapter 6, text | 4th Homework assigned Research question for Proposal Project must be selected and teams identified |
| 10/09/03 | Biological Materials, cont. | |||
| 9 | 10/14/03 | Tissue Response to Implants / FDA | Class Notes | 4th homework due |
| 10/16/03 | Soft Tissue Implants | Chapter 7, text | 5th homework assigned | |
| 10 | 10/21/03 | Blood Interfacing Implants | Class Notes | Articles for Proposal Project identified |
| 10/23/03 | No Class! Fall Break | |||
| 11 | 10/28/03 | Hard Tissue Implants | Chapter 8, text | |
| 10/30/03 | Hard Tissue Implants, cont. | 5th Homework due | ||
| 12 | 11/04/03 | Considerations in Testing Biomaterials | Class Notes | 6th Homework assigned (Lab?) |
| 11/06/03 | Considerations in Testing Biomaterials, Cont. | |||
| 13 | 11/11/03 | Intro to Tissue Engineering | Class Notes | Outline for Proposal Project Due |
| 11/13/03 | Tissue Engineering, cont. | Review Articles | ||
| 14 | 11/18/03 | "Catch-up", Review for Exam II | 6th Homework due Journal Club II articles assigned |
|
| 11/20/03 | Examination II | |||
| 15 | 11/25/03 | Journal Club II Review Presentation Guidelines |
Medical Device Analysis Due | |
| 11/27/03 | No class! Thanksgiving Break | |||
| 16 | 12/02/03 | Medical Device Discussions Review Exam II |
Draft 1 Proposal Project Due | |
| 12/04/03 | Proposal Project Presentations | Journal Club III articles assigned | ||
| 17 | 12/09/03 | Proposal Project Presentations | ||
| 12/11/03 | Journal Club III - Review of Semester | Final Proposal Project Due |
